ePoster 

Die hochgeladenen ePoster sind nur für eingeloggte Teilnehmende ersichtlich. 

Bitte loggen Sie sich ein, um zu den ePoster zu gelangen. 

 

Detaillierte Beitrags-Information

Zurück zur Liste

Beitragstitel Simple conjunctival epithelial transplantation (SCET) combined to keratectomy: a novel approach for the treatment of Aniridia Associated Keratopathy in a patient with congenital aniridia.
Beitragscode P05
Autor:innen
  1. François Majo Centre Ophtalmologique de la Gare Präsentierende:r
  2. Aleksandra PETROVIC Grand-Pont Ophtalmologie
Präsentationsform Poster Flash Presentation & ePoster
Themengebiete
  • External Disease / Cornea
  • Cataract / Refractive Surgery / Contact Lens
Abstract-Text Purpose: To describe a new surgical procedure and its outcomes i.e. Keratectomy and SCET (Simple Conjunctival Epitehlial Transplantation) to treat Aniridia Associated Keratopathy (AAK).
Method: A 48 year old man underwent Keratectomy and SCET to treat aniridia associated keratopathy in his two eyes. Preoperative clinical features were stage IV AAK with corneal neovascularization on 360°, vortex like fluorescein pattern of the cornea and central corneal opacity. Preoperative BUVA and BCVA were HM in the right eye (RE) and CF at 0.5m in the left eye (LE). RE was pseudophakic with artificial iris, intraocular pressure was 17 mmHg, fundus examination was impossible. LE had a cataract, intraocular pressure was 18 mmHg, fundus examination was impossible. Corneal sensitivity was low in the two eyes. Preoperative corneal OCT of the two eyes showed hyperreflective and thickened epithelial layer and central stromal opacity extended to 250 microns into the stroma. The SCET uses bulbar conjunctiva and not limbal stem cells as it was described in the original simple limbal epithelial transplantation (SLET) technique by Sangwan. In the RE keratectomy was 100 micrometers thick and was performed with a FEMTOLASER (Z8 from Ziemer®) and in the LE the keratectomy was 250 micrometers thick and was performed with the Moria® Microkeratome. The epithelial cells were taken from the ipsilateral bulbar conjunctiva. Ten conjunctival autografts of 1mm diameter were fixed on the residual corneal stroma using fibrin glue without amniotic membrane. A bandage contact lens was placed at the end of the surgery. Post operative treatments were topical ofloxacine (Floxal®, Bausch &Lomb, Canada) and dexamethasone (Dexafree®, Théa Pharma, France).
Results: Mean follow-up was 28 months for the RE and 8 months for the LE. Post operative BUVA and BCVA were 0.04 in the RE and CF at 2 meters in the LE. Corneal neovascularization and CCO disappeared in the two eyes with no recurrences after more then two years in the RE. Corneal re epithelialization was completed after 30 days in the two eyes.
Conclusion: SCET was efficient in preventing corneal neovascularization and stabilizing the corneal epithelium for more than two years and seems to represent a potentially good alternative to allogenic SLET or allogenic limbal graft, avoiding systemic immunosuppression. Further investigations and series of cases are necessary to confirm this new surgical procedure in this clinical condition.